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baskexact - Analytical Calculation of Basket Trial Operating Characteristics

Analytically calculates the operating characteristics of single-stage and two-stage basket trials with equal sample sizes using the power prior design by Baumann et al. (2024) <doi:10.48550/arXiv.2309.06988> and the design by Fujikawa et al. (2020) <doi:10.1002/bimj.201800404>.

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openblascpp

5.37 score 2 stars 2 dependents 13 scripts 444 downloads

basksim - Simulation-Based Calculation of Basket Trial Operating Characteristics

Provides a unified syntax for the simulation-based comparison of different single-stage basket trial designs with a binary endpoint and equal sample sizes in all baskets. Methods include the designs by Baumann et al. (2025) <doi:10.1080/19466315.2024.2402275>, Schmitt and Baumann (2025) <doi:10.1080/19466315.2025.2486231>, Fujikawa et al. (2020) <doi:10.1002/bimj.201800404>, Berry et al. (2020) <doi:10.1177/1740774513497539>, and Neuenschwander et al. (2016) <doi:10.1002/pst.1730>. For the latter two designs, the functions are mostly wrappers for functions provided by the package 'bhmbasket'.

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jagscpp

5.16 score 2 stars 2 dependents 5 scripts 485 downloads

blindrecalc - Blinded Sample Size Recalculation

Computation of key characteristics and plots for blinded sample size recalculation. Continuous as well as binary endpoints are supported in superiority and non-inferiority trials. See Baumann, Pilz, Kieser (2022) <doi:10.32614/RJ-2022-001> for a detailed description. The implemented methods include the approaches by Lu, K. (2016) <doi:10.1002/pst.1737>, Kieser, M. and Friede, T. (2000) <doi:10.1002/(SICI)1097-0258(20000415)19:7%3C901::AID-SIM405%3E3.0.CO;2-L>, Friede, T. and Kieser, M. (2004) <doi:10.1002/pst.140>, Friede, T., Mitchell, C., Mueller-Veltern, G. (2007) <doi:10.1002/bimj.200610373>, and Friede, T. and Kieser, M. (2011) <doi:10.3414/ME09-01-0063>.

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cpp

5.00 score 5 stars 9 scripts 552 downloads

findn - Simulation Based Sample Size Estimation

Estimates the sample size for a test or a trial based on repeated simulation using a model based approach. Implements a method by Maruo et al. (2018) <doi:10.1080/19466315.2017.1349689> and an extension.

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3.30 score 360 downloads